Bispecific Agents for High-Risk Multiple Myeloma

In this Educator Module, Kevin Brigle, PhD, ANP, provides a detailed overview of multiple myeloma staging and risk factors that contribute to high-risk disease and poorer outcomes. Dr. Brigle defines triple-class and penta-drug refractory multiple myeloma and differentiates among bispecific antibodies and their associated toxicities, while providing important key efficacy data. Dr. Brigle closes the discussion with a review of unanswered questions regarding sequencing of bispecific agents and their use as bridging therapy to CAR T-cell therapy. Throughout the module, easy-to-read tables provide clinically useful resources.

Funding and support provided by Janssen Oncology

 



Meet The Faculty


Kevin Brigle, PhD, ANP
Kevin Brigle, PhD, ANP
VCU Massey Comprehensive Cancer Center
Kevin Brigle, PhD, ANP, is an oncology nurse practitioner in the Hematological Malignancies Clinic at the Virginia Commonwealth University Massey Cancer Center in Richmond, VA. He earned his bachelor's degree in biology from the University of Dayton and his doctoral degree in molecular microbiology from Virginia Tech. Following completion of his dissertation, he took a position as a postdoctoral fellow and later as laboratory director in the Division of Hematology and Oncology at Virginia Commonwealth University (VCU). While consulting on an NIH-funded grant in the School of Nursing, Dr. Brigle completed the Nurse Practitioner Program at VCU. Following 1 year of practice as an acute care nurse practitioner in internal medicine, Dr. Brigle came to his current position in the Hematological Malignancies Clinic at the Massey Cancer Center. In addition to his clinical role, Dr. Brigle is adjunct faculty in the School of Nursing and has authored or co-authored 30 peer-reviewed journal articles and 7 book chapters.
Mikhaila Rice, PharmD, BCPS, BCOP
Mikhaila Rice, PharmD, BCPS, BCOP
Cleveland Clinic, Cleveland, Ohio
Mikhaila Rice received a Doctor of Pharmacy degree from the University of Pittsburgh School of Pharmacy. She completed a PGY1 Pharmacy Practice Residency and a PGY2 Oncology Pharmacy Residency at Mayo Clinic Hospital-Rochester. She is a Board Certified Oncology Pharmacist and currently practices as a pharmacy clinical specialist at Cleveland Clinic Main Campus where she works with the inpatient and outpatient lymphoma and multiple myeloma care teams.
Oxana Megherea, PharmD, BCOP
Oxana Megherea, PharmD, BCOP
Abramson Cancer Center at the Hospital of the University of Pennsylvania
Oxana Megherea, PharmD, BCOP is a hematology/oncology clinical pharmacy specialist with the Multiple Myeloma Program at the Abramson Cancer Center at the Hospital of the University of Pennsylvania. She received her Doctor of Pharmacy degree from Temple University School of Pharmacy. She completed her PGY-1 pharmacy practice residency and PGY-2 hematology/oncology residency at the Hackensack University Medical Center and The Johns Hopkins Hospital, respectively. She is a member of pharmacy and interdisciplinary committees within the hospital, as well as an active member of ASH, ACCP, ASTCT, and HOPA. She serves as a preceptor for PGY1 and PGY2 residents, and is also a lecturer and preceptor for local schools of pharmacy. Dr. Megherea has a special interest in hematologic malignancies and cellular therapeutics.